54 articles - From Friday Jun 10 2022 to Friday Jun 17 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis. Using receptor-ligand interactions and downstream target characterisation, we identify RA-specific synovial T cell-derived transforming growth factor (TGF)-ß and macrophage interleukin (IL)-1ß synergy in driving the transcriptional profile of FAPa + THY1 + invasive synovial fibroblasts, expanded in RA compared with PsA. In vitro characterisation of patient with RA synovial fibroblasts showed metabolic switch to glycolysis, increased adhesion intercellular adhesion molecules 1 expression and IL-6 secretion in response to combined TGF-ß and IL-1ß treatment. Disrupting specific immune and stromal cell interactions offers novel opportunities for targeted therapeutic intervention in RA and PsA. |
Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration. The adjusted overall drug discontinuation and 1 |
Interferon-a-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming. Our data suggest that, in eRA, IFN-a can cause a sustained, epigenetically mediated, pathogenic increase in lymphocyte activation and proliferation, and that the IGS is, therefore, a robust prognostic biomarker. Its persistent harmful effects provide a rationale for the initial therapeutic targeting of IFN-a in selected patients with eRA. |
Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids. Our results revealed profound alterations in the methylation and transcriptomic profiles of monocytes from GCA patients, uncovering novel genes and pathways involved in GCA pathogenesis and in the molecular response to GC treatment. |
Optimising both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease. Multivariable linear regression models were performed to identify variables associated with BMD. Results Data from 1066 patients with iRMD were analysed. GC doses of 7.5 mg/day were negatively associated with BMD, but only in patients with moderate to high disease activity. |
Standardisation of ACPA tests: evaluation of a new candidate reference preparation. Adoption of an international standard for ACPA determination is highly desirable. The candidate NIBSC 18/204 standard improved the standardisation and alignment of most ACPA assays and might therefore be recommended to be used as reference in commercial assays. |
The effect of achieving serological remission on subsequent risk of relapse, end-stage renal disease and mortality in ANCA-associated vasculitis: a target trial emulation study. In this emulated target trial from a large AAV cohort, achieving serological remission within 180 days of induction was associated with lower risk of relapse, but no statistically significant difference in ESRD or mortality outcomes. |
Treat-to-target dose reduction and withdrawal strategy of TNF inhibitors in psoriatic arthritis and axial spondyloarthritis: a randomised controlled non-inferiority trial. A T2T TNFi strategy with tapering attempt is non-inferior to a T2T strategy without tapering with regard to the proportion of patients still in LDA at 12 months, and results in a substantial reduction of TNFi use. |
Treatment with tumour necrosis factor inhibitors is associated with a time-shifted retardation of radiographic spinal progression in patients with axial spondyloarthritis. TNFi treatment was associated with a time-shifted effect on radiographic spinal progression in axSpA that became evident between years 2 and 4 after treatment initiation. |
| Arthritis Care Res (Hoboken) |
A Multimodal Prediction Model for Diagnosing Pulmonary Hypertension in Systemic Sclerosis. In patients with SSc, a random forest model can aid in the detection of PH with high sensitivity and specificity, and may allow for better patient selection for RHC, thereby minimizing patient risk. |
Association of the quantity, duration, and type of alcohol consumption on the development of gouty tophi. A longer duration and higher quantity of alcohol consumption as well as spirits consumption are predictors for the development of US-detected tophi and sub-tophi in patients with gout. Among people who have US-detected tophi and sub-tophi, weekly alcohol consumption leads to the development of tophi regardless of amount consumed. |
Effectiveness and Safety of Tofacitinib in Canadian Patients with Rheumatoid Arthritis: Primary Results from the Observational CANTORAL Study. Tofacitinib was associated with early and sustained improvement in RA signs and symptoms in real-world patients. Effectiveness and safety were consistent with the established tofacitinib clinical profile. |
| Arthritis Res Ther |
Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity. As the interrelationship between the two isoforms appear to (a) discriminate between quiescent and active SLE and (b) differ between SLE and AAV, our data indicates that the two CRP isoforms could exert contrasting immunological effects and/or reflect different milieus. Given the biological effects of mCRP, it is possible that altered levels may indicate increased opsonization of immune complexes and apoptotic debris, and thereby prevent their deposition outside the reticuloendothelial system and manifestations such as lupus nephritis and lupus-related skin disease. |
Clinical characteristics and prognosis of patients with antiphospholipid antibodies based on cluster analysis: an 8-year cohort study. We identified 4 clinical phenotypes of aPL-positive patients. Non-criteria manifestations may indicate underlying SLE, for which immunosuppressive therapy besides anticoagulation may be necessary. Patients with isolated LA positivity suffered similar risks with secondary APS and patients with multiple cardiovascular risk factors. Attention should be paid to male patients, and the screening of cardiovascular risk factors should never be ignored. |
Effect of tumor necrosis factor inhibitors on risk of cardiovascular disease in patients with axial spondyloarthritis. Although controlling inflammation through TNFis could be beneficial in cardiovascular risk reduction, our data indicate no TNFi-specific reduction in cardiovascular risk in patients with axSpA. |
Efficacy and safety of HLX01 in patients with moderate-to-severe rheumatoid arthritis despite methotrexate therapy: a phase 3 study. HLX01 plus methotrexate improved clinical outcomes compared with placebo in Chinese patients with rheumatoid arthritis who had inadequate responses to methotrexate. This treatment regimen was well tolerated, showing comparable safety profiles to placebo. |
Global burden of rheumatic heart disease: trends from 1990 to 2019. Pronounced decreasing trends of death and DALYs caused by RHD were observed in regions and countries from 1990 to 2019, but the RHD burden remains a substantial challenge globally. The results would inform the strategies for more effective prevention and control of RHD. |
Peripheral blood CD4posCD25posFoxP3pos cells and inflammatory cytokines as biomarkers of response in rheumatoid arthritis patients treated with CTLA4-Ig. Baseline IL-6 serum levels and peripheral blood-derived CD4 pos subpopulations are putative novel prognostic biomarkers of CTLA4-Ig response in RA patients. |
Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas. This is the first report of the lncRNA profiles in placentas from SLE pregnancies. These results suggest that the aberrant expression and the potential regulatory function of lncRNAs in placentas may play comprehensive roles in the pathogenesis of SLE pregnancies. SLE-dysregulated lncRNAs may potentially serve as biomarkers for SLE. |
Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis. Catabolic effects on cartilage tissue caused by injury and cytokine treatment were reduced with the addition of Dex in this osteochondral PTOA model. This study presents potential peptide biomarkers of early PTOA progression and Dex efficacy that can help identify and treat patients at risk of PTOA. |
Unincreased risk of hospitalized infection under targeted therapies versus methotrexate in elderly patients with rheumatoid arthritis: a retrospective cohort study. The overall IR of HI was increased with age. The risk of HI under TT compared to MTX was not elevated in elderly and older elderly patients after adjusting for patients' characteristics and concomitant treatments. |
| Rheumatology (Oxford) |
Behçet syndrome in children and adults: discovering similarities and differences by a comparative study. Remarkable differences between juvenile-onset and adult-onset BS, both in terms of gender, familiar predisposition, and clinical manifestations have been observed and a different therapeutic approach in the real clinical practice of the two settings emerged. Prospective, comparison studies with a longer follow-up are encouraged to provide further data about the disease course for juvenile and adult-onset BS. |
Changes on chest HRCT in systemic sclerosis-related interstitial lung disease after autologous hematopoietic stem cell transplantation. Real-world data analysis confirmed significant improvement in extent of HRCT SSc-ILD 24 |
Circulating and renal fibrocytes are associated with interstitial fibrosis in lupus nephritis. Fibrocytes were significantly increased in the blood and kidney tissue of patients with LN, especially those with interstitial fibrosis. Fibrocytes could be differentiated from blood cells, with an active contribution from RTECs. Our results show a possible link between fibrocytes and tubulointerstitial fibrosis, which may serve as a novel therapeutic target for LN fibrogenesis. |
Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis. Plasma His levels are a potential biomarker for SLE patients and are associated with damage accrual. Our data suggest the importance of His as a pathogenic metabolite in SLE pathogenesis. |
DNA from macrophages induces fibrosis and vasculopathy through POLR3A/STING/type I interferon axis in systemic sclerosis. SSc presented increased DNA leakage and STING pathway activation. DNA from macrophages induced type I IFN signature of fibroblasts and ECs through POLR3A/STING pathway. Blocking POLR3A/STING axis provides a new therapeutic target for SSc. |
Interstitial lung disease in ANCA-associated vasculitis: associated factors, radiographic features, and mortality. ILD is a frequent complication of AAV, especially MPO-ANCA+ AAV, often preceding recognition of AAV. Fibrotic AAV-ILD is associated with a higher risk of death than AAV without ILD. |
L-shaped association between serum 25-Hydroxyvitamin D and all-cause mortality of individuals with rheumatoid arthritis. L-shaped association between serum 25(OH)D and all-cause mortality was found among patients with RA, indicating that serum 25(OH)D should be improved to a certain level for the prevention of premature death. |
Rituximab dose-dependent infection risk in rheumatoid arthritis is not mediated through circulating immunoglobulins, neutrophils or B-cells. These secondary analyses of the REDO trial confirmed the observed dose-dependent infection risk. Additionally, we found that infection risks were higher shortly after RTX infusion. However, a mediating pathway was not found. |
Severe Libman-Sacks endocarditis complicating antiphospholipid syndrome: a retrospective analysis of 23 operated cases. Severe HVD leading to surgery was strongly associated with thrombotic APS, especially arterial phenotypes. Half of the reported patients presented cerebral stroke complicating the HVD. Valvular surgery carried a significant risk of CAPS. |
Subclinical atherosclerosis profiles in rheumatoid arthritis and primary Sjögren's syndrome: The impact of BAFF genetic variations. Increased inflammatory burden, higher steroid doses and distinct BAFF gene variations imply chronic inflammation and B cell hyperactivity as key contributors for the augmented atherosclerotic risk among autoimmune patients. |
Trajectories of depressive symptoms in systemic lupus erythematosus over time. Four classes of depressive symptoms were identified in patients with SLE. Understanding these trajectories and associated risk factors can aid in the management of depressive symptoms in individuals living with SLE. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Rheumatol |
Letters to the editors and authors’ replies
| Ann Rheum Dis |
| Arthritis Care Res (Hoboken) |
all remaining publications eg case reports, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |